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PipelineIndicationLead IdentificationLO & PCC ProfilingIND EnablingPhase I

Pipeline
SPR1020
Brain-penetrant PARP1 selective inhibitor
Indication
mBC (with/without brain metastases), OC, PDAC, PCa, GBM
Lead IdentificationLO & PCC ProfilingIND EnablingPhase I
Project
SPR2015
KRAS G12D (on) molecular glue
Indication
CRC, PDAC, NSCLC, etc.
Lead IdentificationLO & PCC ProfilingIND EnablingPhase I
Project
SPR03
KRAS G12V (on) molecular glue
Indication
Solid tumors
Lead IdentificationLO & PCC ProfilingIND EnablingPhase I
Project
SPR04
Brain-penetrant HER2 (EGFR sparing) selective inhibitor
Indication
Solid tumors
Lead IdentificationLO & PCC ProfilingIND EnablingPhase I